منابع مشابه
Commentary Helix is a helix is a helix ?
There is much activity directed at quantifying the contribution of specific interactions to the stabilization of protein structure. The paper by Myers et al. (1) in this issue of the Proceedings addresses a central and much studied issue: The experimental measure of the intrinsic a-helix forming propensities of the amino acids. What is an intrinsic a-helix forming propensity? The idea that the ...
متن کاملNikR is a ribbon-helix-helix DNA-binding protein.
Escherichia coli NikR, a repressor with homologs in other bacteria and archaea, was identified as a potential new member of the ribbon-helix-helix (beta-alpha-alpha) family of transcription factors in profile based sequence searches and in structure prediction experiments. Biophysical and biochemical characterization of the N-terminal domain of NikR show that it has many features expected of a ...
متن کاملThe basic helix loop helix transcription factor Twist1 is a novel regulator of ATF4 in osteoblasts.
Parathyroid hormone (PTH) is an essential regulator of endochondral bone formation and an important anabolic agent for the reversal of bone loss. PTH mediates its functions in part by regulating binding of the bone-related activating transcription factor 4 (ATF4) to the osteoblast-specific gene, osteocalcin. The basic helix-loop-helix (bHLH) factors Twist1 and Twist2 also regulate osteocalcin t...
متن کاملA theoretical study on quadrupole coupling parameters of HRPII Protein modeled as 310-helix & α-helix structures
A fragment of Histidine rich protein II (HRP II 215-236) was investigated by 14N and 17O electric field gradient, EFG, tensor calculations using DFT. This study is intended to explore the differences between 310-helix and α-helix of HRPII both in the gas phase and in solution. To achieve the aims, the 17O and 14N NQR parameters of a fragment of HRPII (215-236) for both structures are calculated...
متن کاملID helix-loop-helix proteins
The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1997
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.94.7.2796